Acute toxicity (dermal)

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Term Acute toxicity (dermal)
Description
Definition The test substance is applied to the skin in graduated doses to several groups of experimental animals, one dose being used per group. Subsequently, observations of effects and deaths are made. Animals which die during the test are necropsied and at the conclusion of the test surviving animals are necropsied.

Animals showing severe and enduring signs of distress and pain may need to be humanely killed. Dosing test substances in a way known to cause marked pain and distress due to corrosive or irritating properties need not be carried out.

References 1. http://ecb.jrc.ec.europa.eu/documents/Testing-Methods/ANNEXV/B03web1992.pdf

2. http://www.oecd.org/dataoecd/17/46/1948333.pdf

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