Acute toxicity - fixed dose procedure

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Term Acute toxicity - fixed dose procedure
Description The method is used for determine of acute toxicity. It is equivalent to OECD TG 420 (2001).
Definition Traditional methods for assessing acute toxicity use death of animals as an endpoint. In 1984, a new approach to acute toxicity testing was suggested by the British Toxicology Society based on the administration at a series of fixed dose levels. The approach avoided using death of animals as an endpoint, and relied instead on the observation of clear signs of toxicity at one of a series of fixed dose levels. Following UK and international in vivo validation studies the procedure was adopted as a testing method in 1992. Subsequently, the statistical properties of the Fixed Dose Procedure have been evaluated using mathematical models in a series of studies. Together, the in vivo and modelling studies have demonstrated that the procedure is reproducible, uses fewer animals and causes less suffering than the traditional methods and is able to rank substances in a similar manner to the other acute toxicity testing methods.
References 1. http://ecb.jrc.ec.europa.eu/documents/Testing-Methods/ANNEXV/B01bisweb2004.pdf
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